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It is widely used as a paint stripper and degreaser.

In the food industry, it has been used to decaffeinate coffee and chocolate, as well as to prepare hop extracts and other flavoring agents.

Its volatility has led to its use as an aerosol spray propellant and as a blowing agent for polyurethane foams.

The low boiling point of the chemical compound allows the chemical to operate in a heat engine that can extract mechanical energy from small temperature differences. An example of a DCM heat engine is a drinking bird. The toy operates at room temperature.

DCM chemically welds some plastics together. For example, it is used to seal the housing of electricity meters. Often sold as the main component of plastic welding adhesives, it is also widely used by model-making hobbyists to assemble plastic components. It is often referred to as "Di-clo".

It is used in the garment printing industry to lift heat-sealed garment transfers and utilizes elements of playful novelty: bubble lights and music box images.

DCM is used in the field of materials testing in civil engineering; in particular, during the testing of bituminous materials as a solvent, it is used to separate the binder from an asphalt or macadam aggregate, allowing the materials to be tested.